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吴毅

点击:10    发布/更新时间: 2023-03-21

吴毅

  

教授,博士生导师

复旦大学附属华山医院康复医学科

联系方式:办公室电话(02152887820

Emailwuyi4000@163.com

研究方向:慢性病管理、急危重症护理


教育背景

  

1983年毕业于同济医科大学(原武汉医学院),获医学学士学位

1990年毕业上海医科大学研究生院,获医学硕士学位

2007年毕业复旦大学研究生院毕业,获医学博士学位



教学及科研情况

  

曾主持国家自然科学基金项目9项,国家科技部(863计划)项目1项,国家重点研发项目子课题1项。发表学术论文100余篇,被SCI收录40余篇。培养博士后3名,博士生20余名,硕士研究生30余名。获得中国康复医学会科技进步奖一等奖,中华医学科技奖二等奖、教育部科技奖二等奖、上海市科技进步奖二等奖和国家科技进步二等奖(第八完成人)等奖项各1项。

主编《社区康复适宜技术》、《内外科疾病康复学实训指导》、《康复医学学习指导与习题集》、《康复医学》(全国高等学校八年制教材)、《医师定考,康复医学分册》、《康复医学概论》等教材。



学术任职

  

复旦大学上海医学院康复医学系主任,上海市医学会物理医学与康复学专科分会主任委员,中国康复医学会脑功能检测与调控康复专业委员会主任委员,上海市医师协会康复医师分会前任会长。

《中华物理医学与康复杂志》副总编辑,《中国康复医学杂志》副主编,《康复学报》副主编。



近五年主要论文

  


Liu L, Ding M, Wu J, Zhang Y, Guo S, Wang N, Wang H, Yu K, Weng Y, Luo L, Zhang J, Zhang Q, Qiu K, Wu Y, Xiao X, Zhang Q. Design and evaluation of a rodent-specific focal transcranial magnetic stimulation coil with the custom shielding application in rats[J]. Frontiers In Neuroscience. 2023, 17: 1129590.

 Li H, Liu J, Tian S, Fan S, Wang T, Qian H, Liu G, Zhu Y, Wu Y, Hu R. Language reorganization patterns in global aphasia–evidence from fNIRS[J]. Frontiers in Neurology. 2023, 13.

Zhang Q Q, Luo L, Liu M X, Wang C J, Wu Y, Yu K W. Enriched Environment-Induced Neuroprotection against Cerebral Ischemia-Reperfusion Injury Might Be Mediated via Enhancing Autophagy Flux and Mitophagy Flux [J]. Mediators of Inflammation. 2022: 2396487.

Wang T, Tai J, Hu R, Fan S, Li H, Zhu Y, Wu Y, Wu J. Effect of Tongue-Pressure Resistance Training in Poststroke Dysphagia Patients with Oral Motor Dysfunction: A Randomized Controlled Trial [J]. American Journal of Physical Medicine and Rehabilitation. 2022, 101(12): 1134-1138.

Luo L, Liu M, Fan Y, Zhang J, Liu L, Li Y, Zhang Q, Xie H, Jiang C, Wu J, Xiao X, Wu Y. Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4/NFκB/NLRP3 signaling pathway in cerebral ischemic mice [J]. Journal of Neuroinflammation. 2022, 19(1).

He Z, Lu R, Guan Y, Wu Y, Ge J, Liu G, Chen Y, Xie H, Wu J, Jia J. Brain Metabolic Connectivity Patterns in Patients with Prolonged Disorder of Consciousness after HypoxicIschemic Injury: A Preliminary Study [J]. Brain Sciences. 2022, 12(7).

Han X, Shen H, Chen J, Wu Y. Efficacy and safety of electrical stimulation for stress urinary incontinence in women: a systematic review and meta-analysis[J]. International Urogynecology Journal. 2022, 33(4): 789-799.

Gu T, Hao P, Chen P, Wu Y. A Systematic Review and Meta-Analysis of the Effectiveness of High-Intensity Interval Training in People with Cardiovascular Disease at Improving Depression and Anxiety[J]. Evidence-based Complementary and Alternative Medicine. 2022: 8322484.

Zhu Y T, Zhang Q, Xie H Y, Yu K W, Xu G J, Li S Y, Wu Y. Environmental enrichment combined with fasudil promotes motor function recovery and axonal regeneration after stroke[J]. Neural Regeneration Research. 2021, 16(12): 2512-2520.

Xu G J, Zhang Q, Li S Y, Zhu Y T, Yu K W, Wang C J, Xie H Y, Wu Y. Environmental enrichment combined with fasudil treatment inhibits neuronal death in the hippocampal CA1 region and ameliorates memory deficits[J]. Neural Regeneration Research. 2021, 16(8): 1460-1466.

Luo L, Liu M, Xie H, Fan Y, Zhang J, Liu L, Li Y, Zhang Q, Wu J, Jiang C, Wu Y. High-Intensity Interval Training Improves Physical Function, Prevents Muscle Loss, and Modulates Macrophage-Mediated Inflammation in Skeletal Muscle of Cerebral Ischemic Mice[J]. Mediators of Inflammation. 2021: 1849428.

Lou M M, Tang X Q, Wang G M, He J, Luo F, Guan M F, Wang F, Zou H, Wang J Y, Zhang Q, Xu M J, Shi Q L, Shen L B, Ma G M, Wu Y, Zhang Y Y, Liang A B, Wang T H, Xiong L L, Wang J, Xu J, Wang W Y. Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons[J]. Nature Communications. 2021, 12(1): 4075.

 Liu L, Zhang Q, Li M, Wang N, Li C, Song D, Shen X, Luo L, Fan Y, Xie H, Wu Y. Early post-stroke electroacupuncture promotes motor function recovery in post-ischemic rats by increasing the blood and brain irisin[J]. Neuropsychiatric Disease and Treatment. 2021, 17: 695-702.

Liu G, Chia C H, Wang W N, Cao Y, Tian S, Shen X Y, Chen Y, Lu R R, Wu J F, Zhu Y L, Wu Y. The Muscle Activation Differences in Post-Stroke Upper Limb Flexion Synergy Based on Spinal Cord Segments: A Preliminary Proof-of-Concept Study[J]. Frontiers in Neurology. 2021, 12: 598554.

Chia C H, Tang X W, Cao Y, Cao H T, Zhang W, Wu J F, Zhu Y L, Chen Y, Lin Y, Wu Y, Zhang Z, Yuan T F, Hu R P. Cortical excitability signatures for the degree of sleepiness in human[J]. ELife. 2021, 10.

YU K, KUANG S, WANG C, et al. Changes in Mitochondria-Associated Protein Expression and Mitochondrial Function in Response to 2 Weeks of Enriched Environment Training After Cerebral Ischaemia-Reperfusion Injury [J]. Journal of Molecular Neuroscience. 2020, 70(3): 413-421.

Siyue Li, Zhong-Ming Qian, Gaojing Xu, Jie Zheng, Yi Wu. Hepatocyte growth factor protects PC12 cells against OGD/R-induced injury by reducing iron [J]. Bioscience Reports.  2020, 40: 1-9.

Yu KW, Wang CJ, Wu Y, Wang YY, Wang NH, Kuang SY, Liu G, Xie HY, Jiang CY, Wu JF. An enriched environment increases the expression of fibronectin type III domain-containing protein 5 and brain-derived neurotrophic factor in the cerebral cortex of the ischemic mouse brain [J]. Neural Regeneration Research. 2020, 15(9): 1671-1677. 

Xie H, Zhang Q, Zhou N, Li C, Yu K, Liu G, Wu J, Jiang C, Hu R, Wu Y. Environmental enrichment enhances post-ischemic cerebral blood flow and functional hyperemia in the ipsilesional somatosensory cortex [J]. Brain Research Bulletin. 2020, 160: 91–97.  

Liu G, Li XM, Tian S, Lu RR, Chen Y, Xie HY, Yu KW, Zhang JJ, Wu JF, Zhu YL, Wu Y. The effect of magnetic stimulation on differentiation of human induced pluripotent stem cells into neuron [J]. Journal of Cellular Biochemistry. 2020, 121(10): 4130-4141. 

Chuan-Jie Wang, Yi Wu, Qun Zhang, Ke-Wei Yu, Yu-Yang Wang. An enriched environment promotes synaptic plasticity and cognitive recovery after permanent middle cerebral artery occlusion in mice [J]. Neural Regeneration Research. 2019. 14(3): 462-469.

Qun Zhang, Jun-fa Wu, Qi-li Shi, Ming-yue Li, Chuan-jie Wang, Xin Wang, Wen-yuan Wang, Yi Wu. The Neuronal Activation of Deep Cerebellar Nuclei Is Essential for Environmental Enrichment-Induced Post-Stroke Motor Recovery [J]. Aging and Disease. 2019, 10(3):530-543.  

Xie H, Yu K, Zhou N, Shen X, Tian S, Zhang B, et al. Enriched Environment Elicits Proangiogenic Mechanisms After Focal Cerebral Ischemia [J]. Translational Stroke Research. 2019, 10(2): 150-159. 

Wang X, Meng Z, Wang J, Zhou H, Wu Y, Wu J. Enriched environment improves working memory impairment of mice with traumatic brain injury by enhancing histone acetylation in the prefrontal cortex [J]. PeerJ. 2018, 6:e6113.

徐高静,吴毅.康复治疗新技术对脑卒中后脑可塑性影响的研究进展[J].中华物理医学与康复杂志. 2019, 2: 150-153. 

贾晋瑄,吴毅.经颅磁刺激技术在脊髓损伤后痉挛中的应用机制进展[J/OL].中国康复理论与实践. 2019(06):644-647.

杨青,吴毅.脑卒中患者空间注意障碍的认知康复研究进展[J].中华物理医学与康复杂志. 2018,40(8):630-633. 

李修齐,余克威,吴毅.经颅磁刺激治疗卒中后吞咽困难的研究进展[J],康复学报. 201828(3)68-72. 

吴毅,精准康复在重症颅脑损伤后意识障碍诊治中的作用[J].中康复学报. 2018, 28 (2):5-10.

吴毅.颅脑损伤后无创性脑功监测与神经调控技术的研究进展[J].中国康复医学杂志. 2018,33(12):1383-1387.

杨青,胡瑞萍,吴军发,杜小霞,朱玉连,汤昕未,范顺娟,田闪,吴毅.持续短阵脉冲刺激抑制一侧初级运动皮层后脑皮层功能连接的变化[J].中国康复医学杂志. 2018,33(12): 1394-1398,1404. 

汤昕未,胡瑞萍,朱玉连,范顺娟,吴军发,余克威,谢鸿宇,吴毅.间歇性θ短阵脉冲刺激对脑卒中后运动功能障碍的影响[J]. 中国康复医学杂志. 2018,33(12):1415-1410. 

田闪,吴军发,刘罡,陈颖,张备,秦文婷,李丹丹,朱玉连,吴毅.认知能功能训练对脑损伤后假性球麻痹吞咽障碍康复的影响[J].中国临床新医学. 2018,11(1):1-5. 

田闪,胡瑞萍,张备,刘罡,陈颖,谢鸿宇,李丹丹,朱玉连,吴毅.吞咽综合训练对脑损伤后真性和假性球麻痹的疗效观察[J].复旦学报(医学版). 2018,45(5):673-677.