吴炅

主任医师 教授 博士生导师

复旦大学附属肿瘤医院常务副院长

联系电话：86-21-64175590-88607

E-mail：wujiong1122@vip.sina.com

研究方向：慢性病管理、妇幼健康

教学及科研情况

主要致力于乳腺癌早期诊断与疗效预测分子标志物研究，以及乳房肿瘤外科诊疗技术的推广。先后主持国家重点研发计划项目，国家自然科学基金面上项目，上海市科委国际合作项目，（973计划）子课题，复旦大学2020年临床医学研究领航项目等。非编码基因在乳腺癌治疗敏感性调控中的作用、乳腺癌复发转移的分子标记物检测与机制、长链非编码 RNA 在 HER2 阳性乳腺癌新辅助治疗耐药中的作用及机制等方向的研究取得一定成果。已在Oncogene，Molecular Cancer，The Breast J，Clin Cancer Res， Breast Cancer Res Treat等国际知名杂志以第一作者及通讯作者身份发表 SCI 论文100余篇。

同时积极推广和规范乳腺癌保乳、乳腺癌前哨淋巴结活检、乳腺癌乳房重建手术等。主持编撰《乳房肿瘤整形和乳房重建专家共识》及《乳腺癌保乳治疗专家共识》，《乳腺癌术后乳房重建》、《乳腺癌的乳房重建手术》、《RECONSTRUCTION SURGERY IN BREAST CANCER》，并连续多年主办上海市乳房重建论坛。在上海各区县、长三角积极推进肿瘤专科医联体建设，使肿瘤医院的诊疗理念辐射到周边省市，乃至于全国。

获得上海市卫生局首批“医苑新星”，上海市卫生局先进工作者，上海市卫生系统“银蛇奖”，“赛克勒中国医师奖”，国之名医优秀风范奖等，首位获Uccio Querci della Rovere奖的中国大陆医生。

学术任职

现任复旦大学附属肿瘤医院常务副院长，药物临床试验机构主任、一期抗肿瘤新药临床研究中心主任、兼任复旦大学附属肿瘤医院闵行分院（上海市闵行区肿瘤医院）院长。

兼任中国抗癌协会乳腺癌专业委员会主任委员，中国临床肿瘤学会(CSCO)乳腺癌专家委员会副主任委员，中国医师协会外科医师分会乳腺外科医师专委会副主任委员，中国医师协会肿瘤医师分会副主任委员，中华医学会外科学分会乳腺外科学组副组长，中华医学会肿瘤学分会常务委员，上海市医学会肿瘤分会副主委，上海市抗癌协会乳腺癌分会名誉主任委员，曾任上海市医学会肿瘤靶分子专科分会主任委员。

近五年主要论文

Rong Guo, Yonghui Su, Qi Zhang, Bingqiu Xiu, Sheng Huang, Weiru Chi, Liyi Zhang, Lun Li, Jianjing Hou, Jia Wang, Jiajian Chen, Yayun Chi, Jingyan Xue, Jiong Wu. LINC00478-derived novel cytoplasmic lncRNA LacRNA stabilizes PHB2 and suppresses breast cancer metastasis via repressing MYC targets. Journal of Translational Medicine. 2023, 21(1):120.

Qi Zhang, Bingqiu Xiu, Liyi Zhang, Ming Chen, Weiru Chi, Lun Li, Rong Guo, Jingyan Xue, Benlong Yang, Xiaoyan Huang, Zhi-Ming Shao, Shenglin Huang, Yayun Chi, Jiong Wu, Immunosuppressive lncRNA LINC00624 promotes tumor progression and therapy resistance through ADAR1 stabilization. Journal for ImmunoTherapy of Cancer. 2022, 10(10): e004666.

Pei Li, Lun Li, Bingqiu Xiu, Liyi Zhang, Benlong Yang, Yayun Chi, Jingyan Xue, Jiong Wu. The Prognoses of Young Women With Breast Cancer (≤35 years) With Different Surgical Options: A Propensity Score Matching Retrospective Cohort Study. Frontiers in Oncology. 2022, 12(795023).

Yonghui Su, Yuchen Li, Rong Guo, Jingjing Zhao, Weiru Chi, Hongyan Lai, Jia Wang, Zhen Wang, Lun Li, Yuting Sang, Jianjing Hou, Jingyan Xue, Zhimin Shao, Yayun Chi, Shenglin Huang, Jiong Wu. Plasma extracellular vesicle long RNA profiles in the diagnosis and prediction of treatment response for breast cancer, NPJ Breast Cancer. 2021, 7(1): 0-154.

Jia Wang, Bingqiu Xiu, Rong Guo, Qi Zhang, Yonghui Su, Lun Li, Weiru Chi, Zhimin Shao, Jiong Wu. Autologous tissue reconstruction after mastectomy-A cross-sectional survey of 110 hospitals in China. European Journal of Surgical Oncology. 2020, 46(12):2202-2207. 

Benlong Yang, Guosheng Ren, Erwei Song, Da Pan, Jing Zhang, Yongsheng Wang, Ning Liao, Jinhai Tang, Xiang Wang, Shude Cui, Feng Jin, Cuizhi Geng, Qiang Sun, Hongyuan Li, Zhimin Fan, Xuchen Cao, Haibo Wang, Shu Wang, Zhimin Shao, Jiong Wu. Current Status and Factors Influencing Surgical Options for Breast Cancer in China: A Nationwide Cross-Sectional Survey of 110 Hospitals. Oncologist. 2020, 25(10):e1473-e1480.

Rong Guo, Yonghui Su, Jing Si, Jingyan Xue, Benlong Yang, Qi Zhang, Weiru Chi, Jiajian Chen, Yayun Chi, Zhimin Shao, Jiong Wu. A Nomogram for Predicting Axillary Pathologic Complete Response in Hormone Receptor–Positive Breast Cancer with Cytologically Proven Axillary Lymph Node Metastases. Cancer. 2020, 126:3819-3829.

Yayun Chi, Jingyan Xue, Sheng Huang, Bingqiu Xiu, Yonghui Su, Wei Wang, Rong Guo, Lei Wang, Lun Li, Zhiming Shao, Wei Jin, Zhaohui Wu, Jiong Wu. CapG promotes resistance to paclitaxel in breast cancer through transactivation of PIK3R1/P50, Theranostics. 2019, 9(23): 6840-6855.

Bingqiu Xiu, Yayun Chi, Lei Liu, Weiru Chi, Qi Zhang, Jiajian Chen, Rong Guo, Jing Si, Lun Li, Jingyan Xue, Zhi-Ming Shao, Zhao-Hui Wu*, Shenglin Huang, Jiong Wu. LINC02273 drives breast cancer metastasis by epigenetically increasing AGR2 transcription. Molecular Cancer. 2019, 18(1): 0-187.

Yonghui Su, Rong Guo, Jingyan Xue, Yayun Chi, Weiru Chi, Jia Wang, Benglong Yang, Jiong Wu. Increased Mortality with Repeat Lumpectomy Alone After Ipsilateral Breast Tumor Recurrence. Oncologist. 2019, 24(9):e818-e827.